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Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. I. Production, isolation, chemical properties and biological activities.

Authors
  • Naruse, N
  • Tenmyo, O
  • Kawano, K
  • Tomita, K
  • Ohgusa, N
  • Miyaki, T
  • Konishi, M
  • Oki, T
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Jul 01, 1991
Volume
44
Issue
7
Pages
733–740
Identifiers
PMID: 1880063
Source
Medline
License
Unknown

Abstract

Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-L-talose or 3-amino-3,6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.

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