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Fluoxetine in tricyclic refractory major depressive disorder.

Authors
  • Beasley, C M Jr
  • Sayler, M E
  • Cunningham, G E
  • Weiss, A M
  • Masica, D N
Type
Published Article
Journal
Journal of Affective Disorders
Publisher
Elsevier
Publication Date
Nov 01, 1990
Volume
20
Issue
3
Pages
193–200
Identifiers
PMID: 2148340
Source
Medline
License
Unknown

Abstract

Data regarding open-label treatment with fluoxetine following failure to respond to tricyclic antidepressants (TCAs) or intolerance of TCA side effects, suggest a response rate between 51.4% and 62.1%, depending on the definition of TCA refractoriness employed. Double-blind study of this issue would extend these findings. Fluoxetine is well tolerated in patients unable to tolerate TCAs. Within this population, more than 80% of patients unable to tolerate TCAs found fluoxetine acceptable. Fluoxetine, as an alternative to polypharmaceutical augmentation, may represent a logical choice as the next step in therapy for a patient who has initially been treated with a TCA and has proven refractory or intolerant.

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