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Fluoride toothpaste supplemented with sodium hexametaphosphate reduces enamel demineralization in vitro

Authors
  • da Camara, Danielle Mendes1
  • Pessan, Juliano Pelim1
  • Francati, Tamires Melo1
  • Souza, José Antonio Santos1
  • Danelon, Marcelle1
  • Delbem, Alberto Carlos Botazzo1
  • 1 University Estadual Paulista (UNESP), Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil , Araçatuba (Brazil)
Type
Published Article
Journal
Clinical Oral Investigations
Publisher
Springer-Verlag
Publication Date
Jan 13, 2016
Volume
20
Issue
8
Pages
1981–1985
Identifiers
DOI: 10.1007/s00784-015-1707-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveThe aim of this study was to evaluate the effect of fluoride dentifrices combined with sodium hexametaphosphate (HMP) on enamel demineralization in vitro.Material and methodsEnamel bovine blocks were selected by initial surface hardness (SHi) and then divided into five experimental groups (n = 12): placebo (without fluoride and without HMP); 1100 ppm F (1100F); and 1100F associated with HMP at 0.5 % (1100HMP0.5%), 1 % (1100HMP1%), and 2 % of HMP (1100HMP2%). Blocks were submitted to five pH cycles (demineralizing/remineralizing solutions) at 37 °C. After pH cycling, final surface hardness (SHf), percentage of surface hardness loss (%SH), integrated differential hardness (ΔIH), integrated loss of subsurface hardness (ΔKHN), and enamel firmly bound fluoride (F) were determined. Data were submitted to one-way ANOVA, followed by Student–Newman–Keuls test (p < 0.05).ResultsSignificant differences were observed among all groups regarding %SH and ΔKHN. 1100HMP1% promoted the lowest mineral loss among all groups (p < 0.001), and led to significantly lower demineralization in the deeper regions of the subsurface lesion when compared with the other HMP-containing toothpastes (p < 0.001). Significantly higher mineral loss was observed for 1100HMP2% when compared to the other fluoridated dentifrices, mainly in the outer part of the lesion (p < 0.001). Enamel F uptake was similar for 1100F and 1100HMP1% but significantly reduced for other HMP concentrations.ConclusionThe supplementation of a 1100-ppm F dentifrice with 1 % HMP promoted a higher inhibitory effect against enamel demineralization when compared to a dentifrice containing the same amount of fluoride in vitro.Clinical relevanceThis dentifrice could potentially be indicated to patients at high risk of caries.

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