Fluorescent protein tracer studies in allergic reactions: III. Distinguishing characteristics of direct and reversed passive Arthus reactions: The influence of size of antigen and of animal species

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Fluorescent protein tracer studies in allergic reactions: III. Distinguishing characteristics of direct and reversed passive Arthus reactions: The influence of size of antigen and of animal species

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PMC
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  • Biology
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Abstract

Direct and reversed passive Arthus reactions were provoked in various animal species (guinea-pigs, rats, mice), using different antigens (BSA, BGG, ferritin) labelled with lissamine rhodamine. Differences in localization of antigen—antibody precipitate and of granulocytic infiltration were evaluated statistically. The differences both between DPAR and RPAR and between these reactions when provoked with different antigen molecules are interpreted on the base of localization and concentration of antigen and antibody at the start of the reactions as a result of differences in the molecular size and mobility of the proteins involved.

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