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Telomere Shortening and Psychiatric Disorders: A Systematic Review.

Authors
  • Pousa, Pedro A1
  • Souza, Raquel M1
  • Melo, Paulo Henrique M1
  • Correa, Bernardo H M1
  • Mendonça, Tamires S C1
  • Simões-E-Silva, Ana Cristina1
  • Miranda, Débora M2
  • 1 Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais 30130-100, Brazil. , (Brazil)
  • 2 Department of Pediatrics, Laboratory of Molecular Medicine, UFMG, Belo Horizonte, Minas Gerais 30130-100, Brazil. , (Brazil)
Type
Published Article
Journal
Cells
Publisher
MDPI AG
Publication Date
Jun 07, 2021
Volume
10
Issue
6
Identifiers
DOI: 10.3390/cells10061423
PMID: 34200513
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress ("Traumatic Stress Disorder" or "Anxiety Disorder" or "depression") and telomere length ("cellular senescence", "oxidative stress" and "telomere") was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening.

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