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Fludarabine + prednisone +/- alpha-interferon followed or not by alpha-interferon maintenance therapy for previously untreated patients with chronic lymphocytic leukemia: long term results of a randomized study.

Authors
  • Mauro, Francesca R
  • Zinzani, Pierluigi
  • Zaja, Francesco
  • Gentile, Massimo
  • Vegna, Maria Luce
  • Stefoni, Vittorio
  • Marin, Luciana
  • Fanin, Renato
  • Baccarani, Michele
  • Tura, Sante
  • Mandelli, Franco
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Dec 01, 2003
Volume
88
Issue
12
Pages
1348–1357
Identifiers
PMID: 14687987
Source
Medline
License
Unknown

Abstract

In previously untreated CLL patients with advanced disease a high response rate is obtained from first-line fludarabine and prednisone and no benefit is derived from the addition of IFN-alpha to this regimen. The achievement of a good quality response to therapy was the only independent predictor of a prolonged response.

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