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Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization.

Authors
  • Kern, Wolfgang
  • Bacher, Ulrike
  • Schnittger, Susanne
  • Dicker, Frank
  • Alpermann, Tamara
  • Haferlach, Torsten
  • Haferlach, Claudia
Type
Published Article
Journal
British Journal of Haematology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2014
Volume
164
Issue
4
Pages
565–569
Identifiers
DOI: 10.1111/bjh.12652
PMID: 24236747
Source
Medline
Keywords
License
Unknown

Abstract

Multiparameter flow cytometry (MFC) identifies rare cases of biclonal disease in chronic lymphocytic leukaemia (CLL). By MFC, we identified 76 patients with biclonal disease in a cohort of 5523 CLL patients (1·4%). Fluorescence in situ hybridization and chromosome banding analysis revealed five and six cases, respectively, with two different cytogenetic aberrations due to clonal evolution. Two different B-cell receptor rearrangements and IGHV subtypes were more frequent in biclonal than in monoclonal CLL by MFC (37·1% vs. 2·7%; P < 0·001). Patients with biclonal CLL by MFC showed a trend to a shorter time to treatment than monoclonal CLL (P = 0·080).

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