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FLOSS: flexible ordered subset analysis for linkage mapping of complex traits.

Authors
  • Browning, B L
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Feb 15, 2006
Volume
22
Issue
4
Pages
512–513
Identifiers
PMID: 16368771
Source
Medline
License
Unknown

Abstract

The FLOSS software package is a flexible framework for ordered subset analysis. FLOSS is specifically designed for use with the Merlin linkage analysis package, but FLOSS can be used with any linkage analysis software package that reports NPL Z-scores for each locus and family. When FLOSS is used with the Merlin linkage analysis package, one can use either non-parametric Z-scores or Kong and Cox linear allele sharing model LOD scores. Monte Carlo P-values are calculated using a permutation test with an efficient Besag-Clifford sequential stopping rule. FLOSS also has a flexible tool for assigning family covariate scores from Merlin input files. FLOSS includes user documentation and is written in Java for easy portability. The FLOSS source code is documented and designed to be extensible.

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