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Flexible PCL tube scaffolds by winding of micro-extruded filaments

Authors
  • Ragaert, Kim
  • Cardon, Ludwig
  • Degrieck, Joris
Publication Date
Jan 01, 2012
Identifiers
DOI: 10.1201/b11341-18
OAI: oai:archive.ugent.be:1906395
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

An important requirement for tissue engineering scaffolds is matching of the functional me-chanical properties to their natural tissue counterpart. Specifically for arteries this comprises the elastic re-sponse of the vessel wall to blood pressure. Human aorta has a low elastic modulus when compared to some FDA-approved synthetic polymer materials frequently used in tissue engineering. The current research en-deavours to expand the existing production technology of 3D plotting to winding of micro-extruded filaments in order to obtain flexible polymer tubes with continuous fibre. Tube scaffolds are manufactured by conven-tional 3D plotting and by winding. Their structure and quasi-static mechanical properties are evaluated and compared to human aorta. Winded tubes are found to be far more suitable for application as a blood vessel scaffold than their 3D plotted counterparts.

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