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Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats

Authors
  • Garbacki, Nancy1
  • Tits, Monique2
  • Angenot, Luc2
  • Damas, Jacques1
  • 1 CHU, Tour 3, Université de Liège, Laboratoire de Physiologie humaine, Avenue de l'Hôpital, 3, Sart Tilman, B-4000, Belgium , Sart Tilman
  • 2 CHU, Tour 4, Université de Liège, Laboratoire de Pharmacognosie (C.P.S.N.S.), avenue de l'Hôpital 1, Sart-Tilman, B-4000, Belgium , Sart-Tilman
Type
Published Article
Journal
BMC Pharmacology
Publisher
BioMed Central
Publication Date
Oct 21, 2004
Volume
4
Issue
1
Identifiers
DOI: 10.1186/1471-2210-4-25
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundThe anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats.ResultsPretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.) reduced paw oedema induced by carrageenin in a dose and time-dependent manner. PACs also inhibited dose-dependently carrageenin-induced pleurisy in rats. They reduced (A) lung injury, (B) pleural exudate formation, (C) polymorphonuclear cell infiltration, (D) pleural exudate levels of TNF-α, IL-1β and CINC-1 but did not affect IL-6 and IL-10 levels. They reduced (E) pleural exudate levels of nitrite/nitrate (NOx). In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-α, IL-1β, IL-6 and IL-10 but not in NOx were reduced. These data suggest that the anti-inflammatory properties of PACs are achieved through a different pattern from those of indomethacin.ConclusionThese results suggest that the main mechanism of the anti-inflammatory effect of PACs mainly lies in an interference with the migration of the leukocytes. Moreover, PACs inhibited in vivo nitric oxide release.

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