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Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells.

Authors
  • Woo, Yoonkyung
  • Shin, Soon Young
  • Hyun, Jiye
  • Lee, Sung Dae
  • Lee, Young Han
  • Lim, Yoongho
Type
Published Article
Journal
International Journal of Molecular Medicine
Publisher
Spandidos Publications
Publication Date
Mar 01, 2012
Volume
29
Issue
3
Pages
403–408
Identifiers
DOI: 10.3892/ijmm.2011.857
PMID: 22160193
Source
Medline
License
Unknown

Abstract

Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined.

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