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Flagging performance of Sysmex XN-10 haematology analyser for malaria detection.

Authors
  • Dumas, Cécile1
  • Tirard-Collet, Pauline2
  • Mestrallet, Fanélie3
  • Girard, Sandrine3
  • Jallades, Laurent4
  • Picot, Stéphane2, 5
  • Bienvenu, Anne-Lise6, 5
  • 1 Service d'Hématologie Biologique, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France [email protected] , (France)
  • 2 Service de Parasitologie et Mycologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France. , (France)
  • 3 Service d'Hématologie Biologique, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France. , (France)
  • 4 Service d'Hématologie Biologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France. , (France)
  • 5 Malaria Research Unit, SMITh, ICBMS UMR 5246 CNRS, Université de Lyon, Faculte de Medecine Lyon-Est, Lyon, France. , (France)
  • 6 Service d'Hématologie Biologique, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France. , (France)
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
Oct 01, 2020
Volume
73
Issue
10
Pages
676–677
Identifiers
DOI: 10.1136/jclinpath-2019-206382
PMID: 32034055
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm. We retrospectively studied 584 blood samples performed on the Sysmex XN-10 analyser that were tested for malaria. Sensitivity, specificity, positive and negative predictive values, and prevalence were established for the pRBC alarm. Sensitivity, specificity, and positive and negative predictive values for the pRBC flag were 7.8%, 100%, 100% and 87.7%, respectively. The prevalence of pRBC flag of 0.026% in the overall population was significantly different from the prevalence of 1.027% in the population tested for malaria. Considering the excellent specificity and the low prevalence of the flag in the overall population, we suggest, in case of the presence of pRBC flag, the implementation of a rapid review of the blood smear looking for Plasmodium, mostly if the patient had fever and had not been tested for malaria. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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