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The five-year effects of testosterone replacement therapy on lipid profile and glucose tolerance among hypogonadal men in Japan: a case control study.

Authors
  • Kato, Yuki1
  • Shigehara, Kazuyoshi1
  • Nakashima, Kazufumi1
  • Iijima, Masashi1
  • Kawagushi, Shohei1
  • Nohara, Takahiro1
  • Izumi, Kouji1
  • Kadono, Yoshifumi1
  • Konaka, Hiroyuki2
  • Namiki, Mikio3
  • Mizokami, Atsushi1
  • 1 Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. , (Japan)
  • 2 Department of Urology, Kanazawa Red Cross Hospital, Kanazawa, Japan. , (Japan)
  • 3 Department of Urology, Hasegawa Hospital, Toyama, Japan. , (Japan)
Type
Published Article
Journal
The aging male : the official journal of the International Society for the Study of the Aging Male
Publication Date
Mar 01, 2020
Volume
23
Issue
1
Pages
23–28
Identifiers
DOI: 10.1080/13685538.2018.1550060
PMID: 30651019
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objective: This study investigated the efficacy of 5-year testosterone replacement therapy (TRT) on lipid profile and glucose tolerance in Japanese hypogonadal men.Methods: Fourteen patients, who received continuous TRT for 5 years, and 22 controls with 5-year observations were enrolled. The patients in the TRT group had received intramuscular injections of testosterone enanthate (250 mg) every month for 5 years. We collected the following data: blood pressure, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), total cholesterol, triglyceride (TG), high density lipoprotein-Chol values, and prostate specific antigen (PSA) level at baseline, 1-, 3-, and 5-years from initial intervention. These data were compared between the two groups.Results: There were no statistically significant differences in any other baseline characteristic, excluding SBP, between the two groups. FBS was significantly improved at 3- and 5-year visits in the TRT group compared to the control group. Furthermore, the HbA1c level and TG value demonstrated a significant decrease at 1-, 3-, and 5-years in the TRT group. However, no significant difference in changes to PSA levels from baseline in both groups was observed.Conclusions: Five-year TRT could improve FBS, HbA1c, and TG levels among Japanese hypogonadal men with no significant increase in PSA.

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