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Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta.

Authors
  • Jie, Xiao-Xia
  • Geng, Chang-An
  • Huang, Xiao-Yan
  • Ma, Yun-Bao
  • Zhang, Xue-Mei
  • Zhang, Rong-Ping
  • Chen, Ji-Jun
Type
Published Article
Journal
Fitoterapia
Publisher
Elsevier
Publication Date
Apr 01, 2015
Volume
102
Pages
96–101
Identifiers
DOI: 10.1016/j.fitote.2015.02.009
PMID: 25721422
Source
Medline
Keywords
License
Unknown

Abstract

Five new secoiridoid glycosides, swericinctosides A and B (1-2), 9-epi swertiamarin (3), 2'-O-m-hydroxybenzoyl swertiamarin (4), 4″-O-acetyl swertianoside E (5), and one unusual lactonic enol ketone, 3-(hydroxymethyl ene) dihydro-2H-pyran-2, 4(3H)-dione (6), together with three known compounds, swertiaside (7), swertianoside C (8) and decentapicrin B (9) were isolated from Swertia cincta. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, UV, IR and [α]D spectra. Anti-HBV assay on HepG 2.2.15 cell line in vitro demonstrated that compounds 1-9 possessed inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.83mM, and compounds 1, 3, 5, 7 and 8 could inhibit the secretion of HBsAg with IC50 values from 0.24 to 1.06mM.

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