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Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density

Authors
  • Brodin, Alvin T. S.1
  • Gabulya, Sarolta2
  • Wellfelt, Katrin1
  • Karlsson, Tobias E.1
  • 1 Department of Neuroscience, Karolinska Institutet, Solna , (Sweden)
  • 2 Institute of Neuroinformatics, University of Zurich and ETH, Zürich , (Switzerland)
Type
Published Article
Journal
Frontiers in Synaptic Neuroscience
Publisher
Frontiers Media S.A.
Publication Date
Mar 14, 2022
Volume
14
Identifiers
DOI: 10.3389/fnsyn.2022.854160
PMID: 35359703
PMCID: PMC8964138
Source
PubMed Central
Keywords
Disciplines
  • Neuroscience
  • Original Research
License
Unknown

Abstract

Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that 5 h of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from a single episode of sleep deprivation.

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