Tomato is one of vegetables most cultivated in greenhouses, standing out among the plants adapted to this cropping system. The production and fruit quality are directly related to the quality of water used for irrigation and its appropriate management. In order to propose management strategies for use of saline water irrigation in tomato crop production, the present study aimed to evaluate the growth and development of plants, yield and quality, and antioxidant responses of tomato cultivated under a partial salt stress of the root system. The experiment was carried out in a greenhouse at the Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró, RN, Brazil. The experimental design was completely randomized, with six treatments and four replicates, totaling 24 experimental units. The treatments consisted of six different irrigation managements using low and high saline water (S1-0.5 and S2-5.0 dS m-1), applied with or without the partial root-zone saline irrigation (PRSI). For the treatments T1, T2 and T3, the PRSI was not applied, whilst T4*, T5* and T6* treatments were under the PRSI. The number of leaves, leaf area, plant height, stem diameter and dry weight of leaf, stem, root and, fruit were determined as plant growth parameters. Cross diameter, lengthwise diameter, number of fruits per plant, mass average fresh fruit, yield, pH, pulp firmness, soluble solids content, titratable acidity, vitamin C, color relation (a*/b*), lycopene and β-carotene were determined as parameters for the fruit yield and quality evaluation, while antioxidante enzymes were used for oxidative stress evaluation. According to results, it was not observed deleterious effect of salinity on plant growth and assimilates, since that responses observed in all treatments were similar to T1 treatment (control). The best results of yield and quality responses were observed in T4* and T5* treatments. About antioxidants responses, the PRSI did not influence on results obtained for leaf, fruit and root, whereas GR activity was negatively influenced by the use of PRSI. The system PRSI, in the right way shown as a viable alternative for the reduction of negative effects provoked by the salty stress in the hybrid tomato Supera F1.