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First trimester prenatal diagnosis by chorionic villus sampling. The Johannesburg experience with 48 cases.

Authors
  • Rosendorff, J
  • Jacobson, M J
  • Morris, D
  • Ramsay, M
  • Lane, A B
  • Bernstein, R
Type
Published Article
Journal
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Publication Date
Jan 07, 1989
Volume
75
Issue
1
Pages
15–17
Identifiers
PMID: 2643173
Source
Medline
License
Unknown

Abstract

Chorionic villus sampling (CVS) is a first trimester alternative to amniocentesis for the prenatal detection of genetic disorders. Initial experience in 48 patients, in whom transcervical CVS was utilised for the diagnosis of chromosomal, biochemical or molecular disorders, is reported. An adequate villus sample was obtained in all cases and a diagnostic result was achieved in 90% of cases. In this series, the miscarriage rate was 4.2%. It is concluded that CVS appears to be a relatively safe and reliable procedure, but the risk of miscarriage can only be accurately assessed after further investigation.

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