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The first total synthesis of (+)-mucosin.

Authors
  • Henderson, Alan R1
  • Stec, Jozef
  • Owen, David R
  • Whitby, Richard J
  • 1 Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK.
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Apr 07, 2012
Volume
48
Issue
28
Pages
3409–3411
Identifiers
DOI: 10.1039/c2cc17915f
PMID: 22358150
Source
Medline
License
Unknown

Abstract

The first total synthesis of (+)-mucosin has been completed allowing assignment of the absolute stereochemistry of the natural product. A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core.

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