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First natural urease inhibitor from Euphorbia decipiens.

Authors
  • Ahmad, Viqar Uddin
  • Hussain, Javid
  • Hussain, Hidayat
  • Jassbi, Amir Reza
  • Ullah, Farman
  • Lodhi, Muhammad Arif
  • Yasin, Amsha
  • Choudhary, Muhammad Iqbal
Type
Published Article
Journal
Chemical and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Publication Date
May 2003
Volume
51
Issue
6
Pages
719–723
Identifiers
PMID: 12808253
Source
Medline
License
Unknown

Abstract

Three new diterpene esters with a myrsinol-type skeleton have been isolated from Euphorbia decipiens BOISS. & BUHSE. The structure elucidation of the isolated compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) experiments. Compounds 1 and 3 are active against prolyl endopeptidase and compound 2 showed inhibitory activity against urease enzyme.

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