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First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review.

Authors
  • Iovene, Maria Rosaria1
  • Pota, Vincenzo2
  • Galdiero, Massimiliano1
  • Corvino, Giusy1
  • Di Lella, Federica Maria1
  • Stelitano, Debora1
  • Passavanti, Maria Beatrice2
  • Pace, Maria Caterina2
  • Alfieri, Aniello2
  • Di Franco, Sveva2
  • Aurilio, Caterina2
  • Sansone, Pasquale2
  • Niyas, Vettakkara Kandy Muhammed3
  • Fiore, Marco4
  • 1 Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples 80138, Italy. , (Italy)
  • 2 Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy. , (Italy)
  • 3 Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. , (India)
  • 4 Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy. [email protected] , (Italy)
Type
Published Article
Journal
World journal of clinical cases
Publication Date
Nov 06, 2019
Volume
7
Issue
21
Pages
3535–3548
Identifiers
DOI: 10.12998/wjcc.v7.i21.3535
PMID: 31750335
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available antibiotics. An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk (August, 1 to October, 18) in patients admitted to the adult polyvalent intensive care unit of the University of Campania "Luigi Vanvitelli" located in Naples. Four episodes occurred in three patients (two patients infected, and one patient colonized). All the strains revealed the production of VIM. After three decades of carbapenem antibiotics use, the emergence of carbapenem-resistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is mandatory. This is, to our knowledge, the first outbreak of VIM-producing Serratia marcescens in Europe. Surveillance policies must be implemented to avoid future outbreaks. ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

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