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Fine-needle aspiration of a solitary pulmonary nodule following treatment of metastatic giant-cell tumor of bone.

Authors
  • Powers, C N
  • Bull, J M
  • Raval, P
  • Schmidt, W A
Type
Published Article
Journal
Diagnostic Cytopathology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 1991
Volume
7
Issue
3
Pages
286–289
Identifiers
PMID: 1879266
Source
Medline
License
Unknown

Abstract

Giant cell tumor (GCT) of bone is a local, variably aggressive neoplasm with high local recurrence and occasional pulmonary metastases. Radiographically guided fine-needle aspiration (FNA) plays a large role in establishing a tissue diagnosis of lung metastases prior to therapeutic intervention. We present a patient with histologically proven pulmonary metastases from a femoral grade II GCT. These lesions were obliterated with combination HT-CT (hyperthermia and chemotherapy). The patient subsequently developed another pulmonary nodule at a site previously occupied by a GCT metastatic deposit. Radiographically guided FNA revealed that this new lesion was an adenocarcinoma, apparently of pulmonary origin. We suggest that this second neoplasm arose within a scar that developed after HT-CT ablation of one of the metastases. Additional intriguing features of this case are the effective HT-CT therapy of GCT metastatic to lung and the extended temporal course (some 16 yr from initial diagnosis to death).

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