Fine-needle aspiration of a solitary pulmonary nodule following treatment of metastatic giant-cell tumor of bone.
- Authors
- Type
- Published Article
- Journal
- Diagnostic Cytopathology
- Publisher
- Wiley (John Wiley & Sons)
- Publication Date
- Jan 01, 1991
- Volume
- 7
- Issue
- 3
- Pages
- 286–289
- Identifiers
- PMID: 1879266
- Source
- Medline
- License
- Unknown
Abstract
Giant cell tumor (GCT) of bone is a local, variably aggressive neoplasm with high local recurrence and occasional pulmonary metastases. Radiographically guided fine-needle aspiration (FNA) plays a large role in establishing a tissue diagnosis of lung metastases prior to therapeutic intervention. We present a patient with histologically proven pulmonary metastases from a femoral grade II GCT. These lesions were obliterated with combination HT-CT (hyperthermia and chemotherapy). The patient subsequently developed another pulmonary nodule at a site previously occupied by a GCT metastatic deposit. Radiographically guided FNA revealed that this new lesion was an adenocarcinoma, apparently of pulmonary origin. We suggest that this second neoplasm arose within a scar that developed after HT-CT ablation of one of the metastases. Additional intriguing features of this case are the effective HT-CT therapy of GCT metastatic to lung and the extended temporal course (some 16 yr from initial diagnosis to death).