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Filaggrin mutations and atopy: consequences for future therapeutics.

Authors
  • Heimall, Jennifer
  • Spergel, Jonathan M
Type
Published Article
Journal
Expert Review of Clinical Immunology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Feb 01, 2012
Volume
8
Issue
2
Pages
189–197
Identifiers
DOI: 10.1586/eci.11.100
PMID: 22288457
Source
Medline
License
Unknown

Abstract

Filaggrin is a key component of the epidermal differentiation complex of the stratum corneum in the epidermal layer of human skin. Loss-of-function mutations in filaggrin have been described in patients with atopic eczema and are associated with an increased risk of atopic sensitization in these individuals. Atopic eczema is the first stage of the atopic march that describes the phenomenon of increased rates of allergic rhinitis and allergic asthma observed in individuals with early atopic dermatitis. The skin barrier disruptions of atopic eczema associated with loss-of-function mutations in filaggrin are thought to provide a nidus for allergic sensitization to food and aeroallergens, which can then lead to increased allergic disease. It is on this foundation that therapies aimed at restoration of barrier function are thought to play a role, not only in the effective treatment of atopic eczema, but also in the prevention of further allergic disease development.

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