Brazilian Forensic Scientists are frequently asked about ballpoint pen manuscripts chronology in documents suspected to be forged. In the recent years, many methods like quantification of 2-PE (2-phenoxyethanol) have been developed on this subject. The validation of these methods only recently has been a concern between scientific forensic community. Researchers studied the behavior of ink on ageing, but few of them concerned about the influence of the paper on the extraction of 2-PE. This study performed the figures of merit evaluation of the quantification of 2-PE using GC/MS, testing the main parameters involved in the reliability of the method (linearity, repeatability, limits of detection and quantification, accuracy and robustness). After, based on a full factorial design with four factors and two repetitions, the authors tested kind of paper, grammage of paper, ink color and three ink ages, to verify the paper influence on the quantity of 2-PE from ink, trough GC/MS analysis. The merit parameters evaluation showed that the method is linear, precise, accurate and robust. The results for the effect of paper showed main effects of the factors and the existence of interactions effects between the kind of paper and paper grammage, and between the kind of paper and other factors.