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Fifty years of experience with chordomas in southeast Scotland.

Authors
  • O'Neill, P
  • Bell, B A
  • Miller, J D
  • Jacobson, I
  • Guthrie, W
Type
Published Article
Journal
Neurosurgery
Publication Date
Feb 01, 1985
Volume
16
Issue
2
Pages
166–170
Identifiers
PMID: 3974827
Source
Medline
License
Unknown

Abstract

We report the clinical presentation and management of 34 patients with a histologically proven chordoma, treated in the neurosurgical departments in Edinburgh and Dundee, over the past 50 years. Although these tumors are commonly regarded as being locally invasive with a variable, but generally slow growth rate, they can metastasize, and this may precede surgical intervention, as in one of our patients. Our cases are compared to those in previously published series, and a comprehensive review of the treatment modalities for tumors at various sites is presented. The optimal treatment to be recommended from our own experience, and that of others, is aggressive operation and radiotherapy. A combination of hyperthermia and chemotherapy has shown some promise, but remains untested, and highlights the need for a multicenter trial with long follow-up to allow the evaluation of new therapeutic approaches.

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