Affordable Access

Access to the full text

Fibroblasts as a source of self-antigens for central immune tolerance

Authors
  • Nitta, Takeshi1
  • Tsutsumi, Masanori1
  • Nitta, Sachiko1
  • Muro, Ryunosuke1
  • Suzuki, Emma C.1
  • Nakano, Kenta2
  • Tomofuji, Yoshihiko1
  • Sawa, Shinichiro3
  • Okamura, Tadashi2
  • Penninger, Josef M.4, 5
  • Takayanagi, Hiroshi1
  • 1 University of Tokyo, Tokyo, Japan , Tokyo (Japan)
  • 2 National Center for Global Health and Medicine, Tokyo, Japan , Tokyo (Japan)
  • 3 Kyushu University, Fukuoka, Japan , Fukuoka (Japan)
  • 4 Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria , Vienna (Austria)
  • 5 University of British Columbia, Vancouver, British Columbia, Canada , Vancouver (Canada)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 24, 2020
Volume
21
Issue
10
Pages
1172–1180
Identifiers
DOI: 10.1038/s41590-020-0756-8
Source
Springer Nature
License
Yellow

Abstract

Takayanagi and colleagues show that thymic medullary fibroblasts can contribute to central tolerance mechanisms by expressing cell-type-specific antigens distinct from those expressed by medullary thymic epithelial cells.

Report this publication

Statistics

Seen <100 times