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Fibrin glue containing fibroblast growth factor type 1 and heparin with autologous endothelial cells reduces intimal hyperplasia in a canine carotid artery balloon injury model.

Authors
  • Zarge, J I
  • Huang, P
  • Husak, V
  • Kim, D U
  • Haudenschild, C C
  • Nord, R M
  • Greisler, H P
Type
Published Article
Journal
Journal of Vascular Surgery
Publisher
Elsevier
Publication Date
May 01, 1997
Volume
25
Issue
5
Identifiers
PMID: 9152311
Source
Medline
License
Unknown

Abstract

In this canine carotid model, FG with FGF-1 and heparin did not induce significant intimal or medial thickening after 10 or 30 days when compared with vessels that were only balloon-injured. The seeding of autologous ECs within the FG/FGF-1/heparin suspension caused a reduction in neointima formation with no concomitant medial thickening 30 days after injury. The use of FG to locally deliver FGF-1 and ECs may have clinical relevance in the inhibition of intimal hyperplasia.

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