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FGF3 from the Hypothalamus Regulates the Guidance of Thalamocortical Axons

Authors
  • Liu, Kuan
  • Lv, Zhongsheng
  • Huang, Hong
  • Yu, Shuyang
  • Xiao, Li
  • Li, Xiang
  • Li, Gang
  • Liu, Fang
Type
Published Article
Journal
Developmental Neuroscience
Publisher
S. Karger AG
Publication Date
Mar 08, 2021
Volume
42
Issue
5-6
Pages
208–216
Identifiers
DOI: 10.1159/000513534
PMID: 33684917
Source
Karger
Keywords
License
Green
External links

Abstract

Thalamus is an important sensory relay station: afferent sensory information, except olfactory signals, is transmitted by thalamocortical axons (TCAs) to the cerebral cortex. The pathway choice of TCAs depends on diverse diffusible or substrate-bound guidance cues in the environment. Not only classical guidance cues (ephrins, slits, semaphorins, and netrins), morphogens, which exerts patterning effects during early embryonic development, can also help axons navigate to their targets at later development stages. Here, expression analyses reveal that morphogen Fibroblast growth factor (FGF)-3 is expressed in the chick ventral diencephalon, hypothalamus, during the pathfinding of TCAs. Then, using in vitro analyses in chick explants, we identify a concentration-dependent effect of FGF3 on thalamic axons: attractant 100 ng/mL FGF3 transforms to a repellent at high concentration 500 ng/mL. Moreover, inhibition of FGF3 guidance functions indicates that FGF3 signaling is necessary for the correct navigation of thalamic axons. Together, these studies demonstrate a direct effect for the member of FGF7 subfamily, FGF3, in the axonal pathfinding of TCAs.

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