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FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts.

Authors
  • Dolivo, David M1
  • Larson, Sara A1
  • Dominko, Tanja2
  • 1 Worcester Polytechnic Institute, Department of Biology and Biotechnology, 100 Institute Road, Worcester, MA, 01609, United States. , (United States)
  • 2 Worcester Polytechnic Institute, Department of Biology and Biotechnology, 100 Institute Road, Worcester, MA, 01609, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Dec 01, 2017
Volume
88
Issue
3
Pages
339–348
Identifiers
DOI: 10.1016/j.jdermsci.2017.08.013
PMID: 28899582
Source
Medline
Keywords
License
Unknown

Abstract

Inhibition of select MAPK signaling pathways can reverse or potentiate anti-fibrotic FGF2 effects on human dermal fibroblasts, as well as exert their effects independently of exogenous FGF2 supplementation.

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