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FGF23 and Fetuin-A Interaction and Mesenchymal Osteogenic Transformation

Authors
  • Mattinzoli, Deborah
  • Ikehata, Masami
  • Tsugawa, Koji
  • Alfieri, Carlo M.
  • Barilani, Mario
  • Lazzari, Lorenza
  • Andreetta, Paola
  • Elli, Francesca M.
  • Mantovani, Giovanna
  • Messa, Piergiorgio
Publication Date
Feb 20, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Fetuin-A interaction called Duolink proximity ligation assay. Mesenchymal cells produce but do not secrete FGF23 and its expression increases during osteo-differentiation. Fibroblast growth factor 23 is also involved in the regulation of Fetuin-A by binding directly to the Fetuin-A promoter and then activating its transcription. Both FGF23 overexpression and addition induced an upregulation of Fetuin-A in the absence of osteo-inducer factors. Fibroblast growth factor 23 and Fetuin-A promoter were increased by osteo-inducer factors with this effect being abolished after FGF23 silencing. In conclusion, both FGF23 and Fetuin-A are present and strictly linked to each other in MSCs with FGF23 driving Fetuin-A production. This mechanism suggests a role for these two proteins in the osteoblast differentiation.

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