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Platelet retention in glass bead columns: Its mechanism and the effect of plasma proteins

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
8
Identifiers
DOI: 10.1016/0049-3848(76)90063-3

Abstract

Abstract A surface of the beads in the columns through which native blood, blood with chelating agents of calcium or blood with adenine compounds were passed, was observed by scanning electron microscope. When ADP induced platelet aggregation taken place on the beads was completely inhibited by chelation of calcium or antagonists of ADP, platelet retention values remained zero or close to zero. In spite of chelation of calcium in the blood, platelets were aggregated on the gamma globulin or bovine fibrinogen-coated glass beads accompanying slight or moderate elevation of the retention values. These results suggest that platelet adhesion onto the glass bead itself has almost no direct influence on the retention values by the columns.

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