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Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Authors
Journal
Marine Drugs
1660-3397
Publisher
MDPI AG
Publication Date
Volume
7
Issue
3
Identifiers
DOI: 10.3390/md7030401
Keywords
  • Review
Disciplines
  • Biology
  • Chemistry
  • Design
  • Medicine

Abstract

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.

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