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Molecularly imprinted solid-phase extraction of (−)-ephedrine from Chinese Ephedra

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
1070
Identifiers
DOI: 10.1016/j.chroma.2005.03.017
Keywords
  • Molecularly Imprinted Solid Phase Extraction
  • (−)-Ephedrine
  • Chinese Ephedra
  • Sample Clean-Up

Abstract

Abstract Method of molecularly imprinted solid phase extraction (MISPE) of (−)-ephedrine from Chinese Ephedra has been developed in the research. The molecularly imprinted polymer (MIP) with good selectivity and affinity for (−)-ephedrine was synthesized with (−)-ephedrine as the template, methacrylic acid as the functional monomer. The washing and elution conditions in MISPE were selected and optimized for efficient analyte extraction and sample clean-up. A clean analytical HPLC base line of ephedra extract was obtained after MISPE, which indicated that the sample pre-treatment was efficient. Good recovery and precision were obtained in the assessment for the MISPE–HPLC procedure, which demonstrated it is a reliable method and can be used for the determination of (−)-ephedrine in herbal ephedra.

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