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A comparative study of efficacy of propofol auto-co-induction versus midazolam propofol co-induction using the priming principle

Authors
Journal
Indian Journal of Anaesthesia
0019-5049
Publisher
Medknow Publications
Publication Date
Volume
54
Issue
6
Identifiers
DOI: 10.4103/0019-5049.72647
Keywords
  • Clinical Investigation
Disciplines
  • Medicine

Abstract

Application of priming principle is well documented in relation to the use of muscle relaxants. The aim of the present study was to evaluate the efficacy of priming technique in relation to induction agents. Clinical efficacy in terms of dose reduction and alteration in peri-intubation haemodynamics was compared in propofol auto-co-induction and midazolam propofol co-induction groups along with a control group. The study was carried out in 90 patients scheduled for upper abdominal surgery, who were randomly divided into three equal groups. Group I received 0.5 mg/kg propofol IV (20% of the pre-calculated induction dose), group II received 0.05 mg/kg IV midazolam and group III received 3 ml of normal saline. This was followed by IV induction with propofol 2 minutes later in all the three groups at a predetermined rate till the bispectral index value of 45 was attained. The results showed a significant decrease in induction dose requirement in both the groups but haemodynamic stability during induction and intubation was more in propofol auto-co-induction group.

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