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Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
148
Identifiers
DOI: 10.1016/0304-3940(92)90823-p
Keywords
  • Tumor Necrosis Factor α
  • Blood-Brain Barrier
  • Pial Vasoreactivity
  • Cns Infection
  • Newborn
Disciplines
  • Biology

Abstract

Abstract Tumor necrosis factor α (TNFα) plays a significant role in the pathogenesis of central nervous system infections. We investigated the effect of intracisternal injection of recombinant human TNFα (50–50,000 IU) on pial vasoreactivity and blood-brain barrier permeability in newborn piglets. The cytokine administration resulted in arterial vasoconstrictions, blood-brain barrier opening for Na-fluorescein (mol. wt. 376 Da) and increased Na-fluorescein uptake in brain regions examined (parietal and occipital cortex, cerebellum, pons/medulla, periventricular white matter) in a dose-dependent manner. TNFα may be involved in the pathophysiology of neonatal brain injuries.

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