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Few-layered boron nitride nanosheet as a non-metallic phosphatase nanozyme and its application in human urine phosphorus detection.

Authors
  • Yu, Linlin1
  • He, Yuting1
  • Zhou, Guofen1
  • Hu, Lianzhe2
  • Wang, Min3
  • 1 Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China. , (China)
  • 2 Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China. [email protected]. , (China)
  • 3 School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China. [email protected]. , (China)
Type
Published Article
Journal
Analytical and Bioanalytical Chemistry
Publisher
Springer-Verlag
Publication Date
Nov 01, 2024
Volume
416
Issue
27
Pages
5993–5999
Identifiers
DOI: 10.1007/s00216-023-05030-w
PMID: 37962608
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Human urine phosphorus (existing in the form of phosphate) is a biomarker for the diagnosis of several diseases such as kidney disease, hyperthyroidism, and rickets. Therefore, the selective detection of phosphate in urine samples is crucial in the field of clinical diagnosis. Herein, we reported the phosphatase-like catalytic activity of few-layered h-BNNS for the first time. As the phosphatase-like activity of few-layered h-BNNS could be effectively inhibited by phosphate, a selective fluorescent method for the detection of phosphate was proposed. The linear range for phosphate detection is 0.5-10 µM with a detection limit of 0.33 µM. The fluorescent method was then explored for the detection of human urine phosphorus in real samples. The results obtained by the proposed method were consistent with those of the traditional method, indicating that the present method has potential application for urine phosphorus detection in clinical disease diagnosis. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

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