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[Fever and lymphadenopathy: acute toxoplasmosis in an immunocompetent patient].

Authors
  • Kaparos, Nikolaos
  • Favrat, Bernard
  • D'Acremont, Valérie
Type
Published Article
Journal
Revue médicale suisse
Publication Date
Nov 26, 2014
Volume
10
Issue
452
Identifiers
PMID: 25562978
Source
Medline
License
Unknown

Abstract

Toxoplasmosis is an infectious disease caused by the intracellular parasite Toxoplasma gondii. In Switzerland about a third of the population has antibodies against this pathogen and has thus already been in contact with the parasite or has contracted the disease. Immunocompetent patients are usually asymptomatic (80-90%) during primary infection. The most common symptom is neck or occipital lymphadenopathy. Serology is the diagnostic gold standard in immunocompetent individuals. The presence of IgM antibodies is however not sufficient to make a definite diagnosis of acute toxoplasmosis. Distinction between acute and chronic toxoplasmosis requires additional serological tests (IgG avidity test). If required, the most used and probably most effective treatment is the combination of pyrimethamine and sulfadiazine, with folinic acid.

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