Affordable Access

Fetoproteins.

Type
Published Article
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
1
Issue
7643
Pages
397–398
Identifiers
PMID: 4189695
Source
Medline
Keywords
  • Alpha Fetoproteins--History
  • Biology
  • Blood Proteins
  • Cancer
  • Diseases
  • Examinations And Diagnoses
  • Fetus
  • Hemic System
  • Hepatic Effects
  • Neoplasms
  • Physiology
  • Pregnancy
  • Reproduction

Abstract

After a brief summary of the discovery of fetoproteins, the pathological implications of them are discussed. An analysis of the antigenic structure of hepatomas induced in mice led to the discovery of this protein's elaboration by the hepatomas. In mice, fragments of the tumor could be maintained in vitro and these synthesized fetoprotein; fetoprotein production could also be maintained after grafting of hepatomas. However, the mouse model is less amenable than the rat because only 30% of mouse vs. 80% of rat hepatomas synthesize fetoprtein. 3 fetoproteins have been studied in the rat model in relation to hepatomas. 2 of the 3 are also found in adult humans (lipoprotein esterase and alpha 2 glycoprotein) and arise in response to both neoplastic and nonneoplastic conditions. The 3rd, globulin antigen L.A. (liquid amniotique) is regularly and specifically associated with primary and transplanted hepatomas. In humans, the association between fetoproteins and hepatocellular carcinoma has been studied since 1965; the commonly cited figure of association is 60%, though important geographical variations may occur. Benign liver tumors, bile duct tumors, and 2ndary liver tumors do not secrete fetoproteins, and the only nonhepatic neoplasm which has been shown to do so is testicular teratoblastoma, with which fetoproteins are associated in about 10% of cases. 2 recent observations on fetoproteins concern laboratory animals. Hepatomas developed in monkeys given N-nitrosodiethylamine, and most of the tumors made fetoprotein. Also, positive fetoprotein tests were found in 5/10 pyridoxine-deficient baboons.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F