Two experiments were performed to examine sow fertility following the pre-weaning injection of gonadotrophin. In experiment 1, sows received PG600 2-days pre-weaning (PW2), on the day of weaning (W) or received no injection and served as controls (CT1). Compared to controls, the injection of PG600 resulted in shorter (P<0.02) wean-estrus intervals and more (P<0.05) sows exhibiting estrus by 7 days after weaning (4.5+/-0.2, 5.1+/-0.3, 6.1+/-0.3 days, and 81.3, 82.9, 68.8%, for PW2, W, and CT1, respectively). No effect of treatment was apparent for farrowing rate or subsequent litter size. In experiment 2, PG600 was injected at 4 days pre-weaning (PW4) and then either GnRH or hCG was injected at the time of weaning. Control (CT2) sows received no injections. Injection of PG600 was associated with shorter (P<0.0001) wean-estrus intervals and a higher (P<0.003) farrowing rate (1.1+/-0.2, 5.1+/-0.2 days, and 94.8, 78.5% for PW4 and CT2, respectively). There was no effect of treatment on subsequent litter size and results were the same for GnRH and hCG treated sows. We conclude that injection of gonadotrophins prior to weaning will result in very short wean-estrus intervals and that, when combined with a hormonally controlled ovulation, sow fertility may be enhanced.