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Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse.

Authors
  • Kang, Su Jin1
  • Lee, Ji Eun2
  • Lee, Eun Kyung3
  • Jung, Dae Hwa4
  • Song, Chang Hyun2
  • Park, Soo Jin2
  • Choi, Seong Hun5
  • Han, Chang Hyun6
  • Ku, Sae Kwang2
  • Lee, Young Joon7
  • 1 The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected] , (North Korea)
  • 2 The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected] , (North Korea)
  • 3 The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected] , (North Korea)
  • 4 HaniBio, Gyeongsan 712-260, Korea. [email protected] , (North Korea)
  • 5 Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected] , (North Korea)
  • 6 Department of Medical History & Literature Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. [email protected] , (North Korea)
  • 7 The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. [email protected] , (North Korea)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Sep 09, 2014
Volume
6
Issue
9
Pages
3536–3571
Identifiers
DOI: 10.3390/nu6093536
PMID: 25207824
Source
Medline
License
Unknown

Abstract

The major components of tea may be significantly influenced according to the type of fermentation, and consequently the effects of different teas will differ. We examined whether green tea fermented with Aquilariae Lignum (fGT) shows a stronger anti-diabetic effect than unfermented green tea (GT) on mice with type 2 diabetes. To evaluate the anti-obesity effect of fGT, we assessed body weight, fecal excretion, serum leptin levels, exocrine pancreatic zymogen granule contents, and periovarian fat weight and adiponectin contents. Blood glucose levels, pancreatic weight, and numbers of pancreatic islet insulin- and glucagon-producing cells were determined to evaluate anti-hypoglycemic effects, while total cholesterol, triglyceride, and low- and high-density lipoprotein levels were determined to evaluate anti-hyperlipidemic effects. The antioxidant effect of fGT was detected by measuring malondialdehyde and glutathione contents and the activities of catalase and superoxide dismutase. fGT showed anti-obesity, anti-hypoglycemic, anti-hyperlipidemia, and antioxidant effects. Additionally, fGT exerted stronger anti-diabetic effects compared with GT. Collectively, these results suggested that fGT fermented with the appropriate amounts of Aquilariae Lignum (49:1) has a stronger effect compared with GT. Thus, fGT is a promising and potent new therapeutic agent for type 2 diabetes.

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