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Feline Immunodeficiency Virus Cell Entry

Authors
  • Susan C. S. Frey
  • Edward A. Hoover
  • James I. Mullins
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.

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