Affordable Access

deepdyve-link
Publisher Website

Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism.

Authors
  • Nicastro, Nicolas1, 2
  • Eger, Antoine F3
  • Assal, Frederic3
  • Garibotto, Valentina4, 5
  • 1 Department of Psychiatry, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK. [email protected]
  • 2 Division of Neurorehabilitation, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland. [email protected] , (Switzerland)
  • 3 Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland. , (Switzerland)
  • 4 Department of Nuclear Medicine, Geneva University Hospitals, Geneva, Switzerland. , (Switzerland)
  • 5 NiMTLab, Faculty of Medicine, University of Geneva, Geneva, Switzerland. , (Switzerland)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Aug 01, 2020
Volume
14
Issue
4
Pages
1199–1207
Identifiers
DOI: 10.1007/s11682-018-9997-7
PMID: 30511120
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. 25 subjects (mean age 71.9 ± 6.7, disease duration at scan 1.7 ± 1.5 years) were included in the study, of whom nine (36%) experienced FOP. No significant between-group difference was observed regarding dopamine transporters striatal uptake (p = 0.64), daily dopaminergic treatment dosage (p = 0.88) and visual hallucinations (p = 0.83). Statistical parametric mapping showed that subjects with FOP had a significantly reduced glucose metabolism in several left frontoparietal areas (p < 0.001), including superior parietal lobule and precuneus. Interregional correlation analysis of these areas showed specific connectivity with right insula and putamen in the FOP subgroup and right orbitofrontal and superior frontal in subjects without FOP. This provides further evidence about the role of a left frontoparietal network and suggest a possible contribution of impaired orbitofrontal reality filtering associated with FOP.

Report this publication

Statistics

Seen <100 times