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Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Experimental Therapeutics

Abstract

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

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