Affordable Access

Correlation between serotonin synthesis and 5-HT1Areceptor binding in the living human brain: A combined α-[11C]MT and [18F]MPPF positron emission tomography study

Authors
Journal
NeuroImage
1053-8119
Publisher
Elsevier
Publication Date
Volume
42
Issue
2
Identifiers
DOI: 10.1016/j.neuroimage.2008.05.009
Keywords
  • Brain Imaging
  • Mood
  • Pet
  • Positron Emission Tomography
  • Serotonin Synthesis
  • 5-Ht1Areceptors
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Serotonin (5-HT) is one of the major neurotransmitters and has been implicated in a wide variety of cerebral functions. Several lines of evidence indicate that 5HT 1A receptors exert a negative feedback in the synthesis and release of serotonin. While most of what is known about serotonin comes from studies in animals, much less empirical evidence exists about the serotonergic system in the living human brain. This study aims to assess the correlation between serotonin synthesis and 5-HT 1A receptor binding using positron emission tomography (PET) in humans. Six healthy male volunteers underwent 2 PET scans in the same day: one measuring α-[ 11C]MT K⁎ [ml/g/min] trapping constant (a measure of serotonin synthesis) and one measuring 5-HT 1A receptor binding potential BP ND with [ 18F]MPPF. Volumes of interest (VOIs) selected a priori included: anterior cingulate cortex (ACC), anterior insula, hippocampus, amygdala, thalamus, hypothalamus and midbrain raphe nuclei. Correlation analyses were conducted voxel-by-voxel and with manually traced VOIs. A significant negative correlation between serotonin synthesis and 5-HT 1A binding potential was found bilaterally in hippocampus and anterior insula and in the left ACC. The combination of [ 18F]MPPF and α-[ 11C]MT PET offers a means to investigate key determinants of 5-HT neurotransmission under physiological and psychopathological conditions in the human brain in vivo.

There are no comments yet on this publication. Be the first to share your thoughts.