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Indomethacin does not alter the effect of pentagastrin on rat gastric defense mechanisms

Authors
Journal
Peptides
0196-9781
Publisher
Elsevier
Publication Date
Volume
17
Issue
1
Identifiers
DOI: 10.1016/0196-9781(95)02056-x
Keywords
  • Mucosal Blood Flow
  • Gastric Mucus
  • Intracellular Ph
  • Stomach
  • Intracellular Dyes
  • Pentagastrin
  • Mucosal Defense Mechanisms
  • Indomethacin

Abstract

Abstract We studied the effect of the prostaglandin synthesis inhibitor, indomethacin, on pentagastrin-associated enhancements of gastric mucosal defense mechanisms, using a microfluorometric technique in which mucus gel thickness, intracellular pH (pH i), gastric mucosal blood flow, and acid secretion were measured simultaneously in vivo. Intravenous infusion with pentagastrin (80 μg/kg/h) increased mucus gel thickness, induced a hyperemic response to luminal acid, and enhanced pH i homeostasis during acid superfusion. Indomethacin, (5 mg/kg, IP) did not alter the effects of pentagastrin on acid output, mucus gel thickness, mucosal blood flow, and pH i homeostasis. Indomethacin alone did not affect any of these measures. We conclude that the enhancement of gastric defense mechanisms due to pentagastrin is independent of prostaglandin synthesis.

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