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Signal transduction via phosphatidylcholine cycles

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
14
Issue
1
Identifiers
DOI: 10.1016/0968-0004(89)90086-8
Disciplines
  • Biology

Abstract

Abstract Phosphatidylcholine turnover cycles can generate second messengers (including diacylglycerol and arachidonic acid). Guanine nucleotide-binding proteins are implicated in the coupling of agonist receptors to the activation of phospholipases A 2, C and D. In many instances, these agonists also stimulate the resynthesis of phosphatidylcholine via activation of CTP:phosphocholine cytidylyltransferase.

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