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Feasibility of home infusion and self-administration of nanofiltered C1 esterase inhibitor for routine prophylaxis in patients with hereditary angioedema and characterization of a training and support program.

Authors
  • Gregory, Cherylann
  • Landmesser, Ladonna M
  • Corrigan, Larry
  • Mariano, David
Type
Published Article
Journal
Journal of infusion nursing : the official publication of the Infusion Nurses Society
Publication Date
Jan 01, 2014
Volume
37
Issue
1
Pages
29–34
Identifiers
DOI: 10.1097/NAN.0000000000000018
PMID: 24384882
Source
Medline
License
Unknown

Abstract

Hereditary angioedema (HAE) is a rare, chronic disease of C1 inhibitor deficiency. Study researchers evaluated the prevalence of home and self-administration of nanofiltered, human-derived C1 esterase inhibitor infusions and the implementation of a nursing training and support program. Home administration rate increased from 49.0% to 75.8%. The percentage who self-administered increased from 20.3% to 43.9%. Doses per week averaged 1.85 at home compared with 1.40 in infusion centers and physicians' offices. Patients required an average of 5 visits to be trained. Self-administration is a viable, feasible option in the management of HAE, which is facilitated by a nurse-managed training and support program.

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