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Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: a 6-yr analysis from the cologne cohort for neutropenic patients.

Authors
  • Vehreschild, Maria J G T
  • von Bergwelt-Baildon, Michael
  • Tran, Liliane
  • Shimabukuro-Vornhagen, Alexander
  • Wisplinghoff, Hilmar
  • Bangard, Christopher
  • Cornely, Oliver Andreas
  • Vehreschild, Jörg Janne
Type
Published Article
Journal
European Journal Of Haematology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2014
Volume
93
Issue
5
Pages
400–406
Identifiers
DOI: 10.1111/ejh.12368
PMID: 24798021
Source
Medline
Keywords
License
Unknown

Abstract

Our results suggest that both prophylactic regimens, POS and POS-MIC are feasible, safe and effective. Our data suggest that bridging with intravenous micafungin could indeed improve exposure to antifungal prophylaxis, which may explain the reduced incidence of pneumonia and IFD in the bridging group.

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