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Fear response-based prediction for stress susceptibility to PTSD-like phenotypes

Authors
  • Jeong, Min-Jae1
  • Lee, Changhee1
  • Sung, Kibong1
  • Jung, Jung Hoon1, 2
  • Pyo, Jung Hyun1
  • Kim, Joung-Hun1
  • 1 Pohang University of Science and Technology (POSTECH), Pohang, Gyungbuk, 37673, Republic of Korea , Pohang (South Korea)
  • 2 Hospital for Sick Children, Toronto, Ontario, Canada , Toronto (Canada)
Type
Published Article
Journal
Molecular Brain
Publisher
BioMed Central
Publication Date
Oct 07, 2020
Volume
13
Issue
1
Identifiers
DOI: 10.1186/s13041-020-00667-5
Source
Springer Nature
Keywords
License
Green

Abstract

Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mechanisms and functional implication remain unclear yet. We found that an increased amount of freezing that animals exhibited in the intertrial interval (ITI) of a stress-enhanced fear learning paradigm, predicts ensuing PTSD-like symptoms whereas resilient mice show ITI freezing comparable to that of unstressed mice. To examine the behavioral features, we developed a systematic analytical approach for ITI freezing and stress susceptibility. Thus, we provide a behavioral parameter for prognosis to stress susceptibility of individuals in the development of PTSD-like symptoms as well as a new mathematical means to scrutinize freezing behavior.

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