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Effects of immunosuppressive agents on the course ofTrypanosoma (Trypanozoon) bruceiinfections in heat-stressed mice

Authors
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiene
0035-9203
Publisher
Oxford University Press
Publication Date
Volume
67
Issue
6
Identifiers
DOI: 10.1016/0035-9203(73)90015-1

Abstract

Abstract Experimental evidence has been obtained showing that x-irradiation or cyclophosphamide treatment of mice previous to inoculation, elevated the level of parasitaemias in mice infected with T. (T.) brucei when the immunosuppressed animals were maintained at 35C. The trypanosomes in these mice appeared to be less pathogenic than in the control animals kept at (22–27°C) normal room temperature. Many bizarre forms of trypanosomes appeared when the immunosuppressed animals were maintained at the high ambient temperature. It is suggested that the reduced pathogenic effects of these trypanosomes to mice and the occurrence of the various morphological forms are due to direct temperature effect on trypanosome organisms.

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