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Vitamin C and premature rupture of chorioamniotic membranes

Authors
Journal
Nutrition Research
0271-5317
Publisher
Elsevier
Publication Date
Volume
18
Issue
2
Identifiers
DOI: 10.1016/s0271-5317(98)00016-5
Keywords
  • Vitamin C
  • Premature Rupture Of Membranes
  • Pregnancy
  • Infection
Disciplines
  • Biology
  • Design
  • Economics
  • Medicine

Abstract

Abstract Premature rupture of membranes (PROM) has been linked to the socioeconomic status of the population, being more frequent in the most deprived populations. In Mexico, the prevalence of PROM is estimated to be approximately 10% and it has been considered to be a leading maternal cause of neonatal mortality. The main objectives of this study were to identify the principal causes of PROM, to consider different levels of organization — epidemiological, clinical, cellular, subcellular, to design preventive strategies, and to consider the nutritional status especially vitamin C levels and cervico-vaginal infections as the main predictive factors of PROM. In cultured cells, we evaluated the role of vitamin C in the synthesis and degradation of collages types I, III and X. At the clinical level, dietary intake and plasma and leukocyte vitamin C concentration was assessed in pregnant women and correlated with the occurrence of PROM. Vitamin C was found to be related to the synthesis/degradation of collagen in culture cells. The presence of infection decreases vitamin C reserves. Vitamin C reserve as judged by its levels in leukocytes at 28–32 weeks of pregnancy has a predictive value in relation to PROM

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